| Description | |
| Notable Features |
The karyotype can be regarded as pseudo-tetraploid with losses. It shows clear signs of endoreduplication, several abnormal chromosomes being present in two copies. There is evidence of Dutrillaux’s monosomic pattern of karyotype evolution with endoreduplication - e.g. 2 copies each of chromosomes 1, 3 and an unbalanced 1;3 translocation; 2 each of 7, 15 and a probable 7;15 translocation. |
| Representative SKY Karyotype |  |
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Consensus: 69, 1 more than mode (68) 2 x 1, 2 x 3, 3 x 2, der(?)t(1;3)(q?;p22-24?) x 2, 4 x 2, iso(4), 5 x 2, 6 x 2, del(6) x 2, 7 x 2, der(7)t(7;15?*) x 2, 8 x 3, 9 x 2, del(9) x 2, 10 x 2, 11 x 3**, 12 x 3, 13 x 3, 14 x 3, 15 x 2, 16 x 2, del(16), 17 x 3, 18 x 2, 19 x 3, 20 x 4, 21 x 3, 22 x 4, X x 2. * fragment is identified by SKY as chromosome 15 but the fragment is very small so this identification is unreliable. ** In 6/10 metaphases there are 3 elevens. In four of these there is a an additional unbalanced 1;18 translocation, der(?)t(1p?;18q?), while in the other 4 metaphases one eleven is replaced by a der(?)t(11;18). A likely explanation is that the consensus should include the 1;18 translocation and three elevens, but in some metaphases one eleven and the 1;18 have combined to yield the single der(?)t(11;18). SKY Karyotype from 10 metaphases but without any confirmation. Mira Grigorova and Paul Edwards, unpublished. |
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