Lung Carcinoma Cell Lines

NCI-H82 [Cellosaurus entry CVCL_1591]

Lung Cancer Cell Line

Description	A hyperdiploid cell line, from lung, metastatic site, pleural efussion carcinoma, held at ATCC. Karyotyped in collaboration with the Sanger Institute.

Notable Features	Hyperdiploid with 10 structural rearrangements, involving chromosomes 1, 2, 3, 5, 6, 7, 8, 17, 19, most of the rearrangements are unbalanced, but one reciprocal translocation t(1;17)(p10;p10), loss of chromosome Y; gain of chromosomes 8, 13, 16, 20, 21. Most cells contained double minutes (DM) involving different chromosomes.

Representative SKY Karyotype


58(57-69), XX, -Y, 1x2, der(1;17)(p10;p10), der(1;7)(q10;p10), 2x2, der(2)t(2;5), 3x2, der(3)t(3;7)(p12;p11), 4x2, 5x2, dup(5), 6x2, 7x2, 8x3, 9x2, 10x2, 11x2, 12x2, der(12)del(12)(q13-qter), 13x3, 14x2, 15x1, der(15)t(15;8;6), 16x3, 17x1, der(1;17)(q10;q10), del(17)(p11-pter), 18x2, 19x2, der(19)t(6;19), 20x3, 21x3, 22x2, dmin * reciprocal translocation


Additional Information