Molecular Cytogenetics of Common Epithelial Cancers > Lung Carcinoma cell lines > NCI-H2171

NCI-H2171   [Cellosaurus entry CVCL_1536]

Lung Cancer Cell Line


A hypodiploid cell line, from lung, metastatic site, pleural affusion carcinoma, held at ATCC. Karyotyped in collaboration with the Sanger Institute.

Notable Features

Hypodiploid with 10 structural rearrangements involving chromosomes 2, 3, 5, 8, 9, 11, 12, 13, 14, 15, 16, 18, 21, losses of chromosomes 4, 5q, 8, 9p, 10 and gain of chromosome 20. Five of the rearrangements  are simple non-reciprocal translocations, one is a complex dicentric and one i(15q). Double minutes were observed in some cells involving chromosomes 3, 5, 6.

Representative SKY Karyotype

42 (42-46), XY, 1x2, der(2)ins(2;12)(q;?), dic(2;12;2;21), 3x1, der(3)t(3;8), 4x1, 5x1, der(5)del(5)(q11-qter)x2, 6x2, 7x2, 8x1, 9x1, der(9)del(9)(p12-pter), 10x1, 11x1, der(11)t(11:?)(hsr11)hsr(12)hsr(?), 12x1, der(12)t(11;12), 13x1, 14x2, der(14)t(12;14), i(15q), 16x2, 17x2, 18x1, der(18)t(13;18)(q13-q14;q22), 19x2, 20x3, 21x2, 22x2, dmin

Additional Information   FISH analysis showed a rearranged marker chromosome comprising hsrs of chromosomes 11 and 12



Lung Cancer Cell Lines