Molecular Cytogenetics of Common Epithelial Cancers > Lung Carcinoma cell lines > NCI-H2122

NCI-H2122   [Cellosaurus entry CVCL_1531]

Lung Cancer Cell Line


A hyperdiploid cell line from lung, metastatic site, pleural effusion adenocarcinoma, held at ATCC. Karyotyped in collaboration with the Sanger Institute.

Notable Features

Hyperdiploid, with 6 structural rearrangements, gains of chromosomes 1, 2, 5, 7, 8, 10, 14, 15q, 17, 20 and 6 clonal structural rearrangements involving chromosomes 1, 8, 14, 10, 12, 19, an inversion of 7 and an isochromosome 15q.  All cells but one had double minutes (DM), the majority involving chromosomes 1 and 4.

Representative SKY Karyotype

55(53-55) XX, 1x2, 2x3, 3x2, 4x2, 5x3, 6x2, 7x2, inv(7)(pq), 8x2, der(8)t(1;8)(q12;q23-q24?), 9x2, 10x2, der(10)t(10;12)(p;q13-14), 11x2, 12x2, 13x2, 14x1, der(14;19)(q10;?), der(14)t(8;14)(q24;q), 15x2, i(15q), 16x2, 17x3, 18x2, 19x2, 20x3, 21x2, 22x2, dmin

Additional Information  



Lung Cancer Cell Lines