Molecular Cytogenetics of Common Epithelial Cancers > Lung Carcinoma cell lines > NCI-H2087

NCI-H2087   [Cellosaurus entry CVCL_1524]

Lung Cancer Cell Line


A hyperdiploid cell line from lung, metastatic site, lymph node adenocarcinoma, held at ATCC. Karyotyped in collaboration with the Sanger Institute.

Notable Features

Hyperdiploid, highly rearranged with 21 clonal structural abnormalities, involving chromosomes 1, 2, 3, 4, 5, 7, 8, 9, 10, 11, 13, 14, 15, 16, 19, 20, some of them complex, losses of chromosomes 4, 18, 19, 21, 22; partial gain of 5, 11, some cells have double minutes. 

Representative SKY Karyotype

49(42-49), X, Y, 1x1, der(1)t(1;11)(q31-32;q13), der(1;15)(q10;q10), 2x2, der(2)t(2;3), 3x1, der(3)t(3;21)(p21;q ), 4x1, 5x2, i(5p), der(5?)t(2;5), der(5?)t(5q;7), 6x2, der(6)t(6;7), 7x1, der(7)del(7), 8x1, der(8)t(12;8;1), der(8)t(18;8;20), 9x1, der(9)t(9q;4;3), der(9)del(9), 10x1, der(10)t(3;10)(?;q24-25), der(10)del(10) a, 11x2, der(11)t(7;11)(?;q22-24), 12x1, der(13;14)(q10;q10)x2, 14x1, , 15x1, 16x2, 17x2, 18x1, 19x1, der(19)t(15;19), 20x1, der(20)t(5/16?;20), der(20)t(4;20), 21x1, 22x1, der(22)t(22;5;3), dmin a

 a in less than 50% of cells

Additional Information  



Lung Cancer Cell Lines