Molecular Cytogenetics of Common Epithelial Cancers > Lung Carcinoma cell lines > NCI-H1437

NCI-H1437   [Cellosaurus entry CVCL_1472]

Lung Cancer Cell Line


A triploid cell line from lung, metastatic site, pleural effusion adenocarcinoma, held at ATCC. Karyotyped in collaboration with the Sanger Institute.

Notable Features

Triploid, highly rearranged, with 16 clonal structural abnormalities. Translocations involve chromosomes 1, 2, 3, 5, 6, 8, 9, 12, 14, 15, 16, 17, 18, 20, 22, with losses of chromosome 4, 5, 6, 8p, 11, 13, 19, 21, Y and gain of 16. The majority of rearrangements are simple and unbalanced. Double minutes (DM) were found in 6 cells, the majority of DM involve chromosomes 1, 5, 8, 11.

Representative SKY Karyotype

61 (58-63) XX, -Y, 1x1, der(1)t(1;14), der(1)del(1), 2x2, der(2)t(2;6), 3x2, 4x2, der(5)dup(5)t(5;11), der(5)t(1;5), 6x1, der(6)t(2;6), der(6;21)(p10;q10) a, 7x3, 8x2, 9x1, der(9)t(1;9)x2, 10x3, 11x2, 12x2, der(12)t(1;12), der(12)t(1;12;3), 13x2, der(8;14)(q10;q10)x2, der(3;14)(p10;q10), 15x3, 16x3, der(16)t(15;16), 17x2, der(17)t(8;17), 18x2, der(18)t(18;10?), 19x2, 20x2, 21x2, 22x2, ider(22)(q10)t(20;22), dmin

a in less than 50% of cells

Additional Information  



Lung Cancer Cell Lines