Lung Carcinoma Cell Lines

NCI-H1395 [Cellosaurus entry CVCL_1467]

Lung Cancer Cell Line

Description	A near triploid cell line from lung adenocarcinoma, held at the ATCC. Karyotyped in collaboration with the Sanger Institute.

Notable Features	Near-triploid, highly rearranged with 22 structural chromosome abnormalities, involving chromosomes 1, 2, 3, 4, 5, 8, 6, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 22. Half of the rearrangements are whole-arm translocations. Chromosome losses involve chromosomes 3, 6, 8p, 9, 10, 18, 21; gains involve chromosomes 5p, 8q, 19p. Isochromosomes involving 5(p), 8(q) and i(15q). In some cells an extended centromeric region of chromosome 1 was observed and double minutes involving chromosome 11 observed in 3 cells.

Representative SKY Karyotype


57 (56-60), X, 1x2, der(1;14)(q10?;q10), der(1;15)(q10;q10)^a, der(1)del(1), 2x2, 3x1, der(3)t(3;20), 4x2, der(4)del(4)t(1;4), 5x3, i(5p)x2, 6x1, der(6)del(6), 7x3, 8x1, i(8q), 9x2, 10^b x2, der(10)t(1;10)^b, 11x2, 12x3, der(13)t(13;15), der(13)t(13;18), der(13)t(1;13), 14x2, 15x2^a, i(15q)^a, der(12;15)(q10;q10)^a, 16x2, der(16)t(1;16), 17x2, der(17)t(1;17)^a, der(17)t(15;17)^a, 18x1, der(18)t(10;18)^a, 19x3, der(19)t(11;19)dup(11), 20x2, der(20)t(2;20), 21x2, 22x1, der(6;22)(p10;q10), der(22)t(18;22), dmin ^a in less than 50% of cells ^b cells have either 2 copies of 10 or one copy and the translocation


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