| Publication number |
CLPUB00727 |
|---|
| Authors |
Eichholtz-Wirth H., Stoetzer O.J., Marx K. |
|---|
| Title |
Radiation-induced cisplatin resistance in two human cell lines. |
|---|
| Citation |
Radioprotection 32:139-140(1997) |
|---|
| Web pages |
https://inis.iaea.org/search/searchsinglerecord.aspx?recordsFor=SingleRecord&RN=30008348 |
|---|
| Abstract |
Cisplatin resistance has been induced in human HT-29 and HeLa cells after
low-dose fractionated gamma-irradiation. The drug resistance is modest and
does not confer cross-resistance to irradiation. Alterations that were
recently shown to correlate with radiation-induced cisplatin resistance in
murine cells are not involved in the resistant HeLa-C3 cells. Scavengers,
such as GSH or metallothioneins are unchanged and there is no alteration
of the cGMP transduction pathway. Preliminary results in HeLa-C3 cells
indicate that resistance is associated with differences of the apoptotic
pathway, with enhancement of the p53 suppressor protein after cisplatin
treatment but unchanged bcl-2 protein expression.
|
|---|
| Cell lines |
CVCL_C5RL; HeLa-C3 |
|---|
