| Abstract |
Since its inception in 1972, the Human Genetic Mutant Cell Repository has
processed more than 7,000 submitted cell cultures, tissue biopsies, and
peripheral blood specimens and provided more than 35,000 cell cultures to
investigators. These activities have resulted in a worldwide reputation
for excellent, well characterized, thoroughly documented, and contaminant-
free cell cultures.
The thirteenth edition of the catalog contains 154 new listings bringing
the total to 3,744 cell cultures.
Special new additions to this edition of the catalog are 70 lymphoblastoid
cultures obtained from a multigeneration maturity onset diabetes of the
young pedigree. This family consists of a large number of affected, at
risk and normal individuals and should be useful to investigators
interested in gene mapping experiments. The HLA histocompatibility type
cell culture collection was expanded by the addition of thirteen new
lymphoblastoid cultures established from children of consanguineous
parents. Lymphoblastoid cultures established from eight members of a
family with Pelizaeus-Merzbacher disease and three patients with
hemophilia B are also new additions to the catalog. Appendix D which
presents the diagrammatic representation of chromosomally aberrant cell
cultures depicting balanced translocations and unbalanced chromosomal
aberrations resulting in specific chromo some segments (whole or part)
being present in single, triple or greater dosages has been updated in
this edition.
On February 1, 1986 the name of the Institute for Medical Research was
changed to the Coriell Institute for Medical Research in honor of its
founder, Dr. Lewis L. Coriell, who retired in 1985. Dr. Coriell provided
leadership , guidance and dedication to the Institute since its beginning
in 1953. He was the Principal Investigator of the NIGMS Human Genetic
Mutant Cell Repository from its inception in 1972 till December 1983. Dr.
Coriell's keen knowledge of the science of cell culture and his sense of
what a cell repository should be guided the NIGMS Repository to its
position as a major national resource for the study of human genetics.
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