| Publication number |
CLPUB00613 |
|---|
| Authors |
Delaunay T., Bazin H., Durieux C., Fievet C., Volle P.-J., Fruchart J.-C. |
|---|
| Title |
Production and characterization of rat monoclonal antibodies directed against human apolipoprotein B. |
|---|
| Citation |
(In book chapter) Rat hybridomas and rat monoclonal antibodies; Bazin H. (eds.); pp.257-263; CRC Press; Boca Raton; USA (1990) |
|---|
| Abstract |
In this chapter, we describe the generation and the characterization of
six cloned and stable LOU rat hybridoma lines which produce antibodies
specific for human apolipoprotein B in large quantities. These monoclonal
antibodies have affinity constants in the range of 109 M-1 and are
specific for all apolipoprotein-B-containing lipoproteins. Comparatively
with the mouse model, no differences in immune response, efficiency of
fusion procedure, and chemical quality of rat monoclonal antibodies were
observed.
|
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| Cell lines |
CVCL_A6BD; LO-HApoB-1 CVCL_A6BE; LO-HApoB-2 CVCL_A6BF; LO-HApoB-3 CVCL_A6BG; LO-HApoB-4 CVCL_A6BH; LO-HApoB-5 CVCL_A6BI; LO-HApoB-6 |
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