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Cellosaurus publication CLPUB00582
| Publication number | CLPUB00582 |
|---|---|
| Authors | Sugimoto T., Kuroda H., Yagyu S., Gotoh T., Osone S., Tamura S., Iehara T., Hosoi H. |
| Title | Cellular and molecular characteristics of established neuroblastoma cell lines. |
| Citation | J. Cancer Res. Therap. Oncol. 7:201.1-201.15(2019) |
| Web pages | https://www.jscholaronline.org/full-text/JCRTO/7_201/Cellular-and-Molecular-Characteristics.php |
| Abstract | From 1984 to 2013, we established 29 childhood tumor cell lines and 16 neuroblastoma (NB) cell lines for cellular and molecular assays. NB diagnosis has been attempted with monoclonal antibodies against NB surface antigens (but not fetal neuroblasts), particularly with monoclonal antibody KP-NAC8. The multipotency of NB has been assessed during differentiation of NB cells into neurons, schwannian cells, smooth muscle cells. Regarding MYCN oncogene amplification (MNA) and tumorigenesis, the correlation between increased MNA and tumorigenesis in parental and subcloned NB cell lines, serum MYCN DNA levels, and MYCN DNA levels in primary tumors, cell lines, and serum in NB patients have been analyzed. Regarding neurotrophin and tyrosine kinase (TRK) family receptors, ciliary neurotrophic factor (CNTF) in NB cell lines have been analyzed, particularly TRK-A, TRK-B, and CNTF in NB cell lines. Differences in chemotherapeutic sensitivity between two NB cell lines derived from the same patient before and after chemotherapy have been discussed. Finally, improvement of NB prognosis with fenretinide, an apoptosis inducer in NB cell lines, and apoptotic induction using gefitinib (EGFR inhibitor) in NB cell lines have been discussed, along with potential novel therapeutic agents. |
| Cell lines | View cell lines |