| Publication number |
CLPUB00395 |
|---|
| Authors |
Enuameh M.S., Volpe L.-A., Jackson M., Foulke J., Chen L.-P., Shapiro B.A., Tian F. |
|---|
| Title |
The generation of an EML4-ALK fusion NSCLC isogenic cell line relevant for drug discovery and development. |
|---|
| Citation |
(In technical document) ATCC application note 25; pp.1-4; ATCC; Manassas; USA (2016) |
|---|
| Web pages |
https://www.atcc.org/resources/application-notes/generation-of-an-eml4-alk-fusion-nsclc-isogenic-cell-line |
|---|
| Abstract |
Gene editing tools such as CRISPR/Cas9 can be used to create isogenic cell
lines, which can be further used to model a specific patient population
for identifying novel, personalized treatment regimens. An isogenic cell
line was created to model cancer patients with the echinoderm microtubule-
associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion
oncogene, a key oncogenic driver, and then tested for its sensitivity to
known selective inhibitors of ALK.
|
|---|
| Cell lines |
CVCL_JK07; A549 EML4-ALK |
|---|
