| Publication number |
CLPUB00394 |
|---|
| Authors |
Todorova K., Ivanov I., Georgieva A., Lazarova S., Milcheva R., Dimitrov P., Dimitrov R., Russev R. |
|---|
| Title |
Fumonisin B1 cytotoxicity and subcellular localization in duck embryo cell line DEC 99. |
|---|
| Citation |
C. R. Acad. Bulg. Sci. 68:617-622(2015) |
|---|
| Web pages |
https://www.researchgate.net/publication/281775443 |
|---|
| Abstract |
A comparative study on the cytotoxic effect of fumonisin B1 (FB1) was
carried out on BALB/c 3T3 and DEC 99 cell lines. The newly tested
cell line DEC 99 appeared as more sensitive than BALB/c 3T3 line according
to the performed Neutral red uptake assay. Light microscopic investigations
of DEC99 cultures treated with FB1 showed altered monolayer with free of
cells spaces and abundance of dead cells. The immunocytochemical techniques
(immunofluorescent and immunogold labelling) proved the influx of the
toxin through the cell membranes. The toxin was visualized in the cytoplasm
and in the nucleus of the treated cells.
|
|---|
| Cell lines |
CVCL_JF07; DEC-99 |
|---|
