| Publication number |
CLPUB00145 |
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| Authors |
Haraguchi M., Takahashi T., Motoyama T. |
|---|
| Title |
Characterization of two hepatoid adenocarcinoma cell lines: with special references to invasive-metastatic activity and chemosensitivity. |
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| Citation |
Bull. Yamagata Univ. Med. Sci. 19:129-140(2001) |
|---|
| Web pages |
https://ci.nii.ac.jp/naid/110000177918/enhttps://jglobal.jst.go.jp/en/detail?JGLOBAL_ID=200902195675773081 |
|---|
| Abstract |
Hepatoid adenocarcinomas, especially primary gastric hepatoid
adenocarcinomas are well known to be a highly malignant tumor since they
easily metastasize to the liver. Two newly established cultured hepatoid
adenocarcinoma cell lines were characterized with special references to
invasive-metastatic activity and chemosensitivity. The TSG11 cell line was
derived from a primary gastric hepatoid adenocarcinoma, the patient of
which ran an aggressive clinical course. Another cell line TGBG3 was
derived from a primary gallbladder hepatoid adenocarcinoma, the patient of
which has been free from disease for 10 years. TSG11 cell showed more
intimate similarity to immature hepatocyte in both aspects of cell
morphology and cell function than TGBG3 cells. However, some experiments
concerning invasive-metastatic activity and chemo-sensitivity done in the
present study did not successfully disclose any evidences that TSG11 cells
had more highly malignant character. Probably the reason why the parent
tumor of TSG11 cells was highly malignant was due to other factors which
were not examined in the present study.
|
|---|
| Cell lines |
CVCL_B472; TGBG3 CVCL_B477; TSG11 |
|---|
