| Abstract |
Nasopharyngeal carcinoma, an epithelial cancer of high incidence in South
China and some African areas, is of great interest for its close
association with EB virus and for the genetic predisposition to it in some
ethnic populations. Recently an epithelial cell line CNE-2 has been
established from a poorly differentiated nasopharyngeal carcinoma which
represents the first of the kind. Cytogenetic analysis of the CNE-2 line
was carried out by chromosome banding technique. It was found that the
chromosome number of the CNE-2 cells varied from 87 to 107 and the modal
number was 104-103. All cells contained a series of structurally abnormal
chromosomes and most of them were either consistent or frequently found.
Among these chromosomes there were two giant markers which, by banding
pattern analysis, proved to be different from the so-called giant A marker
previously found in many lymphoblastoid cell lines of NPC. Comparison
between CNE-2 and CNE, another epithelial cell line which was established
from well differentiated NPC indicated that while they were quite
different in many cytogenetic respects they had three chromosome markers
in common, namely, an iso 8q at (?;3q) and a small acrocentric one. With
finding of these and the giant markers mentioned above the problem whether
there exists a chromosome marker specific for NPC was discussed.
|
|---|
