| Publication number |
CLPUB00134 |
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| Authors |
Alexandrova R., Tsenova W., Jordanova P.K. |
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| Title |
Biological characterization of cell lines established from Mc29-virus induced transplantable chicken hepatoma. |
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| Citation |
(In book chapter) Proceedings of the Balkan scientific conference of biology in Plovdiv (Bulgaria) from 19th till 21st of May 2005; Gruev B., Nikolova M., Donev A. (eds.); pp.34-40; University of Plovdiv; Plovdiv; Bulgaria (2005) |
|---|
| Web pages |
https://web.uni-plovdiv.bg/mollov/bio/bscb2005/part2/34-40.pdf |
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| Abstract |
The cell lines E7 and G9B4 were obtained after cloning of the permanent
cell line LSCC-SF-Mc29, established from a transplantable chicken hepatoma
induced by the myelocytomatosis virus Mc29. It was found that these cells
differ from each other in morphology, karyotype, in vitro and in vivo
growth properties. The results obtained revealed some causal relationship
between alterations in chromosomal number, on one hand, and the
tumorigenicity of the cells on the other. The correlation was - the higher
percentage of the threeploidy, the lower tumorigenicity of the cells. Our
data suggest that these cell lines could be considered as a model for
tumor heterogeneity investigations and could be useful in the attempts to
get a better understanding of the mechanisms involved in (virus-induced)
cancerogenesis.
|
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| Cell lines |
CVCL_T445; LSCC-SF-Mc29 |
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