| Publication number |
CLPUB00047 |
|---|
| Authors |
Gey G.O., Coffman W.D., Kubicek M.T. |
|---|
| Title |
Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium. |
|---|
| Citation |
Cancer Res. 12:264-265(1952) |
|---|
| Web pages |
https://aacrjournals.org/cancerres/issue/12/4 |
|---|
| Abstract |
This is a report of an evaluation in vitro of the growth potential of
normal, early intra-epithelial, and invasive carcinoma from a series of
cases of cervical carcinoma. Comparable cytological and tissue culture
studies were actually carried out on selected biopsies of normal and
neoplastic areas of the same cervix. Thus far, only one strain of
epidermoid carcinoma has been established and grown in continuous roller
tube cultures for almost a year. It grows well in a composite medium of
chicken plasma, bovine embryo extract, and human placenta! cord serum. The
autologous normal prototype is most difficult to maintain under comparable
cultural conditions. Most of the tissue from other cases showed rapid
keratinization of the cells grown in cultures whether from normal or
neoplastic areas. Some of the hormonal aspects of the problem will be
discussed.
|
|---|
| Cell lines |
CVCL_0030; HeLa |
|---|
