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Cellosaurus publication CLPUB00047

Publication number CLPUB00047
Authors Gey G.O., Coffman W.D., Kubicek M.T.
Title Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium.
Citation Cancer Res. 12:264-265(1952)
Web pages https://aacrjournals.org/cancerres/issue/12/4
Abstract This is a report of an evaluation in vitro of the growth potential of normal, early intra-epithelial, and invasive carcinoma from a series of cases of cervical carcinoma. Comparable cytological and tissue culture studies were actually carried out on selected biopsies of normal and neoplastic areas of the same cervix. Thus far, only one strain of epidermoid carcinoma has been established and grown in continuous roller tube cultures for almost a year. It grows well in a composite medium of chicken plasma, bovine embryo extract, and human placenta! cord serum. The autologous normal prototype is most difficult to maintain under comparable cultural conditions. Most of the tissue from other cases showed rapid keratinization of the cells grown in cultures whether from normal or neoplastic areas. Some of the hormonal aspects of the problem will be discussed.
Cell lines CVCL_0030; HeLa