| Publication number |
CLPUB00033 |
|---|
| Authors |
Senin V.M., Buntsevich A.M., Afanasyeva A.V., Kiseleva N.S. |
|---|
| Title |
A new line of murine carcinosarcoma. |
|---|
| Citation |
Exp. Oncol. USSR 5:35-39(1983) |
|---|
| Abstract |
A transplantable: mammary gland tumour arising spontaneously in a A/Sn
female mouse was used as a base to produce a high-metastatic line. During
intramuscular passages the percentage of mice with lung metastases did not
exceed 10%. The method of successive selective subcutaneous
transplantations of metastatic cells into the tail was used for creating a
high-metastatic tumour line. The frequency of lung metastasizing was about
50% even after 2 passages, the level of 90% being reached within the
further three passages. The selection effectiveness was also manifested by
the fact that after twenty selective passages the intra-muscular
inoculation of tumour cells resulted in the appearance of lung metastases
in 50% of recipients.
|
|---|
| Cell lines |
CVCL_E114; CSML-0 |
|---|
