| Cell line name |
NCI-H23/GEM-R |
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| Synonyms |
H23/GEM-R |
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| Accession |
CVCL_ZZ80 |
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| Resource Identification Initiative |
To cite this cell line use: NCI-H23/GEM-R (RRID:CVCL_ZZ80) |
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| Comments |
Population: African American.
Karyotypic information: Has lost chromosome Y (from parent cell line).
Selected for resistance to: ChEBI; CHEBI:175901; Gemcitabine (Gemzar).
Derived from site: In situ; Lung; UBERON=UBERON_0002048. |
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| Sequence variations |
- Mutation; HGNC; 795; ATM; Simple; p.Gln1919Pro (c.5756A>C); ClinVar=VCV000580726; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11389; STK11; Simple; p.Trp332Ter (c.996G>A); ClinVar=VCV000376339; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Met246Ile (c.738G>C); ClinVar=VCV001758655; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Lung adenocarcinoma (NCIt: C3512) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1547 (NCI-H23) |
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| Sex of cell |
Male |
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| Age at sampling |
51Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=15471562; DOI=10.1111/j.1349-7006.2004.tb03257.x; PMCID=PMC11158492
Achiwa H., Oguri T., Sato S., Maeda H., Niimi T., Ueda R.
Determinants of sensitivity and resistance to gemcitabine: the roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer.
Cancer Sci. 95:753-757(2004) PubMed=17237272; DOI=10.1158/1535-7163.MCT-06-0529
Oguri T., Bessho Y., Achiwa H., Ozasa H., Maeno K., Maeda H., Sato S., Ueda R.
MRP8/ABCC11 directly confers resistance to 5-fluorouracil.
Mol. Cancer Ther. 6:122-127(2007) PubMed=18445659; DOI=10.1158/1535-7163.MCT-07-2088
Oguri T., Ozasa H., Uemura T., Bessho Y., Miyazaki M., Maeno K., Maeda H., Sato S., Ueda R.
MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer.
Mol. Cancer Ther. 7:1150-1155(2008) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_ZZ80
|
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| Encyclopedic resources |
Wikidata; Q102114583
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| Entry history |
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| Entry creation | 29-Oct-2020 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 6 |
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