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Cellosaurus SKOV-3/BCRP (CVCL_ZZ42)

[Text version]
Cell line name SKOV-3/BCRP
Accession CVCL_ZZ42
Resource Identification Initiative To cite this cell line use: SKOV-3/BCRP (RRID:CVCL_ZZ42)
Comments Population: Caucasian.
Characteristics: Transfected with a Myc-tagged ABCG2/BCRP.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:74; ABCG2.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Publications

PubMed=15695404
Imai Y., Ishikawa E., Asada S., Sugimoto Y.
Estrogen-mediated post transcriptional down-regulation of breast cancer resistance protein/ABCG2.
Cancer Res. 65:596-604(2005)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZZ42
Encyclopedic resources Wikidata; Q102114919
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number9