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Cellosaurus ZR75B Vb10 (CVCL_ZZ30)

[Text version]
Cell line name ZR75B Vb10
Accession CVCL_ZZ30
Resource Identification Initiative To cite this cell line use: ZR75B Vb10 (RRID:CVCL_ZZ30)
Comments Population: Caucasian.
Doubling time: 38.2 hours (PubMed=9815641).
Selected for resistance to: ChEBI; CHEBI:27375; Vincaleukoblastine (Vinblastine).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5614 (ZR-75-B)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line

Wosikowski K., Regis J.T., Robey R.W., Alvarez M., Buters J.T.M., Gudas J.M., Bates S.E.
Normal p53 status and function despite the development of drug resistance in human breast cancer cells.
Cell Growth Differ. 6:1395-1403(1995)

Wosikowski K., Schuurhuis D., Kops G.J.P.L., Saceda M., Bates S.E.
Altered gene expression in drug-resistant human breast cancer cells.
Clin. Cancer Res. 3:2405-2414(1997)

Cell line databases/resources cancercelllines; CVCL_ZZ30
Encyclopedic resources Wikidata; Q102115159
Entry history
Entry creation29-Oct-2020
Last entry update05-Oct-2023
Version number7