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Cellosaurus ZR75B Tx40 (CVCL_ZZ29)

[Text version]
Cell line name ZR75B Tx40
Accession CVCL_ZZ29
Resource Identification Initiative To cite this cell line use: ZR75B Tx40 (RRID:CVCL_ZZ29)
Comments Population: Caucasian.
Doubling time: 43.5 hours (PubMed=8562478; PubMed=9815641).
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5614 (ZR-75-B)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=8562478
Wosikowski K., Regis J.T., Robey R.W., Alvarez M., Buters J.T.M., Gudas J.M., Bates S.E.
Normal p53 status and function despite the development of drug resistance in human breast cancer cells.
Cell Growth Differ. 6:1395-1403(1995)

PubMed=9815641
Wosikowski K., Schuurhuis D.H., Kops G.J.P.L., Saceda M., Bates S.E.
Altered gene expression in drug-resistant human breast cancer cells.
Clin. Cancer Res. 3:2405-2414(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZZ29
Encyclopedic resources Wikidata; Q102115158
Entry history
Entry creation29-Oct-2020
Last entry update19-Dec-2024
Version number8