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Cellosaurus MDA-MB-231 Vb100 (CVCL_ZZ22)

[Text version]
Cell line name MDA-MB-231 Vb100
Accession CVCL_ZZ22
Resource Identification Initiative To cite this cell line use: MDA-MB-231 Vb100 (RRID:CVCL_ZZ22)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Doubling time: 33.5 hours (PubMed=9815641).
Selected for resistance to: ChEBI; CHEBI:27375; Vincaleukoblastine (Vinblastine).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=9815641
Wosikowski K., Schuurhuis D.H., Kops G.J.P.L., Saceda M., Bates S.E.
Altered gene expression in drug-resistant human breast cancer cells.
Clin. Cancer Res. 3:2405-2414(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZZ22
Encyclopedic resources Wikidata; Q102114519
Entry history
Entry creation29-Oct-2020
Last entry update05-Oct-2023
Version number8