| Cell line name |
BC7/CCR5 |
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| Accession |
CVCL_ZX81 |
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| Resource Identification Initiative |
To cite this cell line use: BC7/CCR5 (RRID:CVCL_ZX81) |
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| Comments |
Population: Caucasian.
Characteristics: CD4 negative.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1606; CCR5.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Cys251Tyr (c.752G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6342; KIT; Simple; p.Arg177His (c.530G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7029; MET; Simple; p.Arg191Trp (c.571C>T); ClinVar=VCV000568557; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Asp (c.1635G>T); ClinVar=VCV000217293; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu970Lys (c.2908G>A); ClinVar=VCV001057635; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Arg682Cys (c.2044C>T); ClinVar=VCV000237466; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:15533; SPRY4; Simple; p.Arg25Trp (c.73C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg267Leu (c.800G>T); ClinVar=VCV000852206; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Childhood T lymphoblastic lymphoma (NCIt: C7210)
T-cell non-Hodgkin lymphoma (ORDO: Orphanet_171918) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1E03 (BC7) |
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| Sex of cell |
Male |
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| Age at sampling |
8Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=11264379; DOI=10.1128/JVI.75.8.3903-3915.2001; PMCID=PMC114881
Means R.E., Matthews T., Hoxie J.A., Malim M.H., Kodama T., Desrosiers R.C.
Ability of the V3 loop of simian immunodeficiency virus to serve as a target for antibody-mediated neutralization: correlation of neutralization sensitivity, growth in macrophages, and decreased dependence on CD4.
J. Virol. 75:3903-3915(2001) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_ZX81
|
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| Encyclopedic resources |
Wikidata; Q102113607
|
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| Entry history |
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| Entry creation | 29-Oct-2020 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 10 |
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