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Cellosaurus DU145-TxR (CVCL_ZX03)

[Text version]
Cell line name DU145-TxR
Accession CVCL_ZX03
Resource Identification Initiative To cite this cell line use: DU145-TxR (RRID:CVCL_ZX03)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0105 (DU145)
Children:
CVCL_ZX04 (DU145-TxR/CxR)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=17440963; DOI=10.1002/pros.20581
Takeda M., Mizokami A., Mamiya K., Li Y.-Q., Zhang J., Keller E.T., Namiki M.
The establishment of two paclitaxel-resistant prostate cancer cell lines and the mechanisms of paclitaxel resistance with two cell lines.
Prostate 67:955-967(2007)

PubMed=29662635; DOI=10.18632/oncotarget.24609
Machioka K., Izumi K., Kadono Y., Iwamoto H., Naito R., Makino T., Kadomoto S., Natsagdorj A., Keller E.T., Zhang J., Mizokami A.
Establishment and characterization of two cabazitaxel-resistant prostate cancer cell lines.
Oncotarget 9:16185-16196(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZX03
Encyclopedic resources Wikidata; Q102113777
Entry history
Entry creation29-Oct-2020
Last entry update05-Oct-2023
Version number7