Cell line name |
DU145-TxR |
Accession |
CVCL_ZX03 |
Resource Identification Initiative |
To cite this cell line use: DU145-TxR (RRID:CVCL_ZX03) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol). Omics: Transcriptome analysis by microarray. Derived from site: Metastatic; Brain; UBERON=UBERON_0000955. |
Sequence variations |
- Mutation; HGNC; 1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Prostate carcinoma (NCIt: C4863) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0105 (DU145) Children:
|
Sex of cell |
Male |
Age at sampling |
69Y |
Category |
Cancer cell line |
Publications | PubMed=17440963; DOI=10.1002/pros.20581 Takeda M., Mizokami A., Mamiya K., Li Y.-Q., Zhang J., Keller E.T., Namiki M. The establishment of two paclitaxel-resistant prostate cancer cell lines and the mechanisms of paclitaxel resistance with two cell lines. Prostate 67:955-967(2007) PubMed=29662635; DOI=10.18632/oncotarget.24609; PMCID=PMC5882326 Machioka K., Izumi K., Kadono Y., Iwamoto H., Naito R., Makino T., Kadomoto S., Natsagdorj A., Keller E.T., Zhang J., Mizokami A. Establishment and characterization of two cabazitaxel-resistant prostate cancer cell lines. Oncotarget 9:16185-16196(2018) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_ZX03
|
Encyclopedic resources |
Wikidata; Q102113777
|
Entry history |
Entry creation | 29-Oct-2020 |
Last entry update | 05-Oct-2023 |
Version number | 7 |
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