ID   EFC-2
AC   CVCL_ZV49
DR   IARC_TP53; 22882
DR   Wikidata; Q98125951
RX   PubMed=2964515;
RX   PubMed=9070656;
RX   PubMed=9090379;
RX   PubMed=9230885;
CC   Sequence variation: Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Homozygous (PubMed=9090379).
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 02-07-20; Last updated: 19-12-24; Version: 7
//
RX   PubMed=2964515; DOI=10.1007/BF00148389;
RA   Yung W.-K.A., Steck P.A., Kelleher P.J., Moser R.P., Rosenblum M.G.;
RT   "Growth inhibitory effect of recombinant alpha and beta interferon on
RT   human glioma cells.";
RL   J. Neurooncol. 5:323-330(1987).
//
RX   PubMed=9070656; DOI=10.1038/sj.onc.1200925;
RA   Ligon A.H., Pershouse M.A., Jasser S.A., Yung W.-K.A., Steck P.A.;
RT   "Identification of a novel gene product, RIG, that is down-regulated
RT   in human glioblastoma.";
RL   Oncogene 14:1075-1081(1997).
//
RX   PubMed=9090379; DOI=10.1038/ng0497-356;
RA   Steck P.A., Pershouse M.A., Jasser S.A., Yung W.-K.A., Lin H.,
RA   Ligon A.H., Langford L.A., Baumgard M.L., Hattier T., Davis T.,
RA   Frye C., Hu R., Swedlund B., Teng D.H.-F., Tavtigian S.V.;
RT   "Identification of a candidate tumour suppressor gene, MMAC1, at
RT   chromosome 10q23.3 that is mutated in multiple advanced cancers.";
RL   Nat. Genet. 15:356-362(1997).
//
RX   PubMed=9230885; DOI=10.1093/jnci/89.14.1036;
RA   Gomez-Manzano C., Fueyo J., Kyritsis A.P., McDonnell T.J., Steck P.A.,
RA   Levin V.A., Yung W.-K.A.;
RT   "Characterization of p53 and p21 functional interactions in glioma
RT   cells en route to apoptosis.";
RL   J. Natl. Cancer Inst. 89:1036-1044(1997).
//