Cellosaurus cell line 131MA (CVCL

Cross-references
Cell line name	131MA
Synonyms	131 Manchester
Accession	CVCL_ZU07
Resource Identification Initiative	To cite this cell line use: 131MA (RRID:CVCL_ZU07)
Comments	Senescence: Senesces at 23 PDL (PubMed=9649131). Derived from site: In situ; Skin; UBERON=UBERON_0002097. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (PubMed=9018113; PubMed=9649131).
Disease	Li-Fraumeni syndrome (NCIt: C3476) Li-Fraumeni syndrome (ORDO: Orphanet_524)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	18Y
Category	Finite cell line
Publications	PubMed=9018113; DOI=10.1038/sj.onc.1200838 Williams K.J., Boyle J.M., Birch J.M., Norton J.D., Scott D. Cell cycle arrest defect in Li-Fraumeni syndrome: a mechanism of cancer predisposition? Oncogene 14:277-282(1997) PubMed=9649131; DOI=10.1038/bjc.1998.364; PMCID=PMC2150396 Boyle J.M., Mitchell E.L.D., Greaves M.J., Roberts S.A., Tricker K., Burt E., Varley J.M., Birch J.M., Scott D. Chromosome instability is a predominant trait of fibroblasts from Li-Fraumeni families. Br. J. Cancer 77:2181-2192(1998)
Encyclopedic resources	Wikidata; Q98125083
Entry history
Entry creation	02-Jul-2020
Last entry update	19-Dec-2024
Version number	8