ID   110MA
AC   CVCL_ZU00
SY   110 Manchester
DR   Wikidata; Q98125018
RX   PubMed=8794843;
RX   PubMed=9018113;
RX   PubMed=9649131;
CC   Senescence: Senesces at 53 PDL (PubMed=9649131).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu180Lys (c.538G>A); ClinVar=VCV000245711; Zygosity=Heterozygous (PubMed=8794843; PubMed=9018113; PubMed=9649131).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C3476; Li-Fraumeni syndrome
DI   ORDO; Orphanet_524; Li-Fraumeni syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   18Y
CA   Finite cell line
DT   Created: 02-07-20; Last updated: 19-12-24; Version: 8
//
RX   PubMed=8794843; DOI=10.1080/095530096145139;
RA   Sproston A.R.M., Boyle J.M., Heighway J., Birch J.M., Scott D.;
RT   "Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate
RT   irradiation.";
RL   Int. J. Radiat. Biol. 70:145-150(1996).
//
RX   PubMed=9018113; DOI=10.1038/sj.onc.1200838;
RA   Williams K.J., Boyle J.M., Birch J.M., Norton J.D., Scott D.;
RT   "Cell cycle arrest defect in Li-Fraumeni syndrome: a mechanism of
RT   cancer predisposition?";
RL   Oncogene 14:277-282(1997).
//
RX   PubMed=9649131; DOI=10.1038/bjc.1998.364; PMCID=PMC2150396;
RA   Boyle J.M., Mitchell E.L.D., Greaves M.J., Roberts S.A., Tricker K.,
RA   Burt E., Varley J.M., Birch J.M., Scott D.;
RT   "Chromosome instability is a predominant trait of fibroblasts from
RT   Li-Fraumeni families.";
RL   Br. J. Cancer 77:2181-2192(1998).
//