Cellosaurus cell line 2674T (CVCL

Cross-references
Cell line name	2674T
Synonyms	2674
Accession	CVCL_ZT95
Resource Identification Initiative	To cite this cell line use: 2674T (RRID:CVCL_ZT95)
Comments	Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Asp (c.734G>A); ClinVar=VCV000012355; Zygosity=Heterozygous (PubMed=2259385; PubMed=7779715).
Disease	Li-Fraumeni syndrome (NCIt: C3476) Li-Fraumeni syndrome (ORDO: Orphanet_524)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	12Y
Category	Finite cell line
Publications	PubMed=2259385; DOI=10.1038/348747a0 Srivastava S., Zou Z.-Q., Pirollo K.F., Blattner W.A., Chang E.H.-P. Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome. Nature 348:747-749(1990) PubMed=7779715; DOI=10.1038/bjc.1995.237; PMCID=PMC2033854 Mirzayans R., Aubin R.A., Bosnich W., Blattner W.A., Paterson M.C. Abnormal pattern of post-gamma-ray DNA replication in radioresistant fibroblast strains from affected members of a cancer-prone family with Li-Fraumeni syndrome. Br. J. Cancer 71:1221-1230(1995)
Encyclopedic resources	Wikidata; Q98125367
Entry history
Entry creation	02-Jul-2020
Last entry update	19-Dec-2024
Version number	7