Cellosaurus logo
expasy logo

Cellosaurus K562 NGLY1 KO c20 (CVCL_ZL54)

[Text version]
Cell line name K562 NGLY1 KO c20
Synonyms NGLY1 KO clone 20; NGLY1c20
Accession CVCL_ZL54
Resource Identification Initiative To cite this cell line use: K562 NGLY1 KO c20 (RRID:CVCL_ZL54)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; 17646; NGLY1.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=31659326; DOI=10.1038/s41592-019-0614-5
Smits A.H., Ziebell F., Joberty G., Zinn N., Mueller W.F., Clauder-Munster S., Eberhard D., Falth Savitski M., Grandi P., Jakob P., Michon A.-M., Sun H., Tessmer K., Burckstummer T., Bantscheff M., Steinmetz L.M., Drewes G., Huber W.
Biological plasticity rescues target activity in CRISPR knock outs.
Nat. Methods 16:1087-1093(2019)

Cross-references
Encyclopedic resources Wikidata; Q98126812
Gene expression databases ArrayExpress; E-MTAB-7061
Proteomic databases PRIDE; PXD010335
Entry history
Entry creation02-Jul-2020
Last entry update02-May-2024
Version number8