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Cellosaurus SH-SY5Y/VCR (CVCL_ZL49)

[Text version]
Cell line name SH-SY5Y/VCR
Accession CVCL_ZL49
Resource Identification Initiative To cite this cell line use: SH-SY5Y/VCR (RRID:CVCL_ZL49)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28445; Vincristine (VCR).
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; 427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (from parent cell line).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0019 (SH-SY5Y)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line

PubMed=3968181; DOI=10.1083/jcb.100.2.588
Meyers M.B., Spengler B.A., Chang T.-D., Melera P.W., Biedler J.L.
Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells.
J. Cell Biol. 100:588-597(1985)

Meyers M.B., Rittmann-Grauer L., O'Brien J.P., Safa A.R.
Characterization of monoclonal antibodies recognizing a Mr 180,000 P-glycoprotein: differential expression of the Mr 180,000 and Mr 170,000 P-glycoproteins in multidrug-resistant human tumor cells.
Cancer Res. 49:3209-3214(1989)

Cell line databases/resources cancercelllines; CVCL_ZL49
Encyclopedic resources Wikidata; Q98132491
Entry history
Entry creation02-Jul-2020
Last entry update05-Oct-2023
Version number8