ID   A388.6TG.c2
AC   CVCL_ZF53
SY   A3886TGc2
DR   cancercelllines; CVCL_ZF53
DR   Wikidata; Q98125444
RX   PubMed=1358434;
RX   PubMed=10942591;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_9555; Tioguanine (6-thioguanine; 6-TG).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg832Cys (c.2494C>T); ClinVar=VCV000936373; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys135Phe (c.404G>T); ClinVar=VCV000376559; Zygosity=Heterozygous (from parent cell line).
CC   Transformant: ChEBI; CHEBI_21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C4819; Skin squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1063 ! A-388
SX   Male
AG   86Y
CA   Cancer cell line
DT   Created: 02-07-20; Last updated: 19-12-24; Version: 8
//
RX   PubMed=1358434;
RA   Conway K., Morgan D., Phillips K.K., Yuspa S.H., Weissman B.E.;
RT   "Tumorigenic suppression of a human cutaneous squamous cell carcinoma
RT   cell line in the nude mouse skin graft assay.";
RL   Cancer Res. 52:6487-6495(1992).
//
RX   PubMed=10942591; DOI=10.1006/excr.2000.4946;
RA   Merrihew R.V., Cruickshank R.D., Conway K., Weissman B.E.;
RT   "Altered response of a human squamous cell carcinoma cell line to 1,
RT   25-dihydroxyvitamin D(3) after transfer of a normal chromosome 11.";
RL   Exp. Cell Res. 259:191-203(2000).
//