Cellosaurus logo
expasy logo

Cellosaurus EH31 (CVCL_ZE32)

[Text][XML][JSON]
Cell line name EH31
Accession CVCL_ZE32
Resource Identification Initiative To cite this cell line use: EH31 (RRID:CVCL_ZE32)
Comments Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
  • Mutation; HGNC; HGNC:6413; KRT10; Simple; p.Leu161_Asp162del (c.481_486delTTGGAC); ClinVar=VCV000066179; Zygosity=Heterozygous (PubMed=20977447).
Disease Epidermolytic ichthyosis (NCIt: C62569)
Autosomal dominant epidermolytic ichthyosis (ORDO: Orphanet_312)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Transformed cell line
Publications

PubMed=20977447; DOI=10.1111/j.1365-2133.2010.10092.x
Jean Christopher Chamcheu, Inger Pihl-Lundin, Cedrique Eteti Mouyobo, Therese Gester, Marie Virtanen, Aristidis Moustakas, Harshad Ambaram Navsaria, Anders Vahlquist, Hans Torma;
Immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype: a useful in vitro model for testing new treatments.
Br. J. Dermatol. 164:263-272(2011)

Cross-references
Encyclopedic resources Wikidata; Q98125960
Entry history
Entry creation02-Jul-2020
Last entry update14-Aug-2025
Version number11