Cellosaurus cell line EH21 (CVCL

Cross-references
Cell line name	EH21
Accession	CVCL_ZE31
Resource Identification Initiative	To cite this cell line use: EH21 (RRID:CVCL_ZE31)
Comments	Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6. Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7. Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16). Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003. Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations	Mutation; HGNC; HGNC:6413; KRT10; Simple; p.Arg156Gly (c.466C>G); ClinVar=VCV000066969; Zygosity=Heterozygous (PubMed=20977447).
Disease	Epidermolytic ichthyosis (NCIt: C62569) Autosomal dominant epidermolytic ichthyosis (ORDO: Orphanet_312)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category	Transformed cell line
Publications	PubMed=20977447; DOI=10.1111/j.1365-2133.2010.10092.x Chamcheu J.C., Pihl-Lundin I., Eteti Mouyobo C., Gester T., Virtanen M., Moustakas A., Navsaria H.A., Vahlquist A., Torma H. Immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype: a useful in vitro model for testing new treatments. Br. J. Dermatol. 164:263-272(2011)
Encyclopedic resources	Wikidata; Q98125959
Entry history
Entry creation	02-Jul-2020
Last entry update	19-Dec-2024
Version number	10