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Cellosaurus EB21 (CVCL_ZE24)

[Text version]
Cell line name EB21
Accession CVCL_ZE24
Resource Identification Initiative To cite this cell line use: EB21 (RRID:CVCL_ZE24)
Comments Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Skin, epidermis; UBERON=UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
  • Mutation; HGNC; 6442; KRT5; Simple; p.Val186Leu (c.556G>T); ClinVar=VCV000014652; Zygosity=Heterozygous (PubMed=19157792).
Disease Epidermolysis bullosa simplex (NCIt: C84692)
Epidermolysis bullosa simplex, generalized severe (ORDO: Orphanet_79396)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_ZE25 ! EB22
Sex of cell Male
Category Transformed cell line
Publications

PubMed=19157792; DOI=10.1016/j.jdermsci.2008.11.003
Chamcheu J.C., Pavez Lorie E., Akgul B., Bannbers E., Virtanen M., Gammon L., Moustakas A., Navsaria H.A., Vahlquist A., Torma H.
Characterization of immortalized human epidermolysis bullosa simplex (KRT5) cell lines: trimethylamine N-oxide protects the keratin cytoskeleton against disruptive stress condition.
J. Dermatol. Sci. 53:198-206(2009)

PubMed=21490615; DOI=10.1038/jid.2011.93
Chamcheu J.C., Navsaria H.A., Pihl-Lundin I., Liovic M., Vahlquist A., Torma H.
Chemical chaperones protect epidermolysis bullosa simplex keratinocytes from heat stress-induced keratin aggregation: involvement of heat shock proteins and MAP kinases.
J. Invest. Dermatol. 131:1684-1691(2011)

PubMed=28765827; DOI=10.1016/j.omtm.2017.06.008; PMCID=PMC5527154
Aushev M., Koller U., Mussolino C., Cathomen T., Reichelt J.
Traceless targeting and isolation of gene-edited immortalized keratinocytes from epidermolysis bullosa simplex patients.
Mol. Ther. Methods Clin. Dev. 6:112-123(2017)

Cross-references
Encyclopedic resources Wikidata; Q98125934
Entry history
Entry creation02-Jul-2020
Last entry update10-Sep-2024
Version number9