ID   Mel 00.08
AC   CVCL_ZD07
SY   mel0.08; 00.08
DR   cancercelllines; CVCL_ZD07
DR   GEO; GSM1507932
DR   Wikidata; Q98127206
RX   PubMed=23685455;
RX   PubMed=25502142;
RX   PubMed=25538140;
CC   From: Leiden University Medical Center; Leiden; Netherlands.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23685455; PubMed=25538140).
CC   Omics: Transcriptome analysis by RNAseq.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 02-07-20; Last updated: 19-12-24; Version: 6
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RX   PubMed=23685455; DOI=10.1038/nature12154;
RA   Kaplon J., Zheng L., Meissl K., Chaneton B., Selivanov V.A.,
RA   Mackay G., van der Burg S.H., Verdegaal E.M.E., Cascante M., Shlomi T.,
RA   Gottlieb E., Peeper D.S.;
RT   "A key role for mitochondrial gatekeeper pyruvate dehydrogenase in
RT   oncogene-induced senescence.";
RL   Nature 498:109-112(2013).
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RX   PubMed=25502142; DOI=10.1038/ncomms6712; PMCID=PMC4428333;
RA   Muller J., Krijgsman O., Tsoi J., Robert L., Hugo W., Song C.,
RA   Kong X.-J., Possik P.A., Cornelissen-Steijger P.D.M., Geukes Foppen M.H.,
RA   Kemper K., Goding C.R., McDermott U., Blank C., Haanen J.B.A.G.,
RA   Graeber T.G., Ribas A., Lo R.S., Peeper D.S.;
RT   "Low MITF/AXL ratio predicts early resistance to multiple targeted
RT   drugs in melanoma.";
RL   Nat. Commun. 5:5712.1-5712.15(2014).
//
RX   PubMed=25538140; DOI=10.15252/msb.20145450; PMCID=PMC4300494;
RA   Smit M.A., Maddalo G., Greig K., Raaijmakers L.M., Possik P.A.,
RA   van Breukelen B., Cappadona S., Heck A.J.R., Altelaar A.F.M.,
RA   Peeper D.S.;
RT   "ROCK1 is a potential combinatorial drug target for BRAF mutant
RT   melanoma.";
RL   Mol. Syst. Biol. 10:772-772(2014).
//