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Cellosaurus 22Rv1-undup2 (CVCL_ZC65)

[Text version]
Cell line name 22Rv1-undup2
Accession CVCL_ZC65
Resource Identification Initiative To cite this cell line use: 22Rv1-undup2 (RRID:CVCL_ZC65)
Comments Population: Caucasian.
Characteristics: The 35Kb tandem duplication of exons 2b-3-CE1-3 of AR that drives the expression of AR variant 7 (ARv7) was corrected using TALEN (PubMed=28928128).
Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Leu597Arg (c.1790T>G); ClinVar=VCV000013968; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7133; KMT2D; Simple; p.Arg1252Ter (c.3754C>T); ClinVar=VCV000167228; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7133; KMT2D; Simple; p.Gln3158Ter (c.9472C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Gln546Arg (c.1637A>G); ClinVar=VCV000045466; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln331Arg (c.992A>G); ClinVar=VCV000421319; Zygosity=Heterozygous (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1045 (22Rv1)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=28928128; DOI=10.1158/0008-5472.CAN-17-0320; PMCID=PMC5654612
Van Etten J.L., Nyquist M.D., Li Y.-M., Yang R.-D., Ho Y., Johnson R., Ondigi O., Voytas D.F., Henzler C., Dehm S.M.
Targeting a single alternative polyadenylation site coordinately blocks expression of androgen receptor mRNA splice variants in prostate cancer.
Cancer Res. 77:5228-5235(2017)

Cross-references
Cell line collections (Providers) Kerafast; EMN026-FP
Cell line databases/resources cancercelllines; CVCL_ZC65
Encyclopedic resources Wikidata; Q98125355
Entry history
Entry creation02-Jul-2020
Last entry update10-Sep-2024
Version number8