ID   22Rv1-undup1
AC   CVCL_ZC64
DR   cancercelllines; CVCL_ZC64
DR   Kerafast; EMN025-FP
DR   Wikidata; Q98125354
RX   PubMed=28928128;
CC   Population: Caucasian.
CC   Characteristics: The 35Kb tandem duplication of exons 2b-3-CE1-3 of AR that drives the expression of AR variant 7 (ARv7) was corrected using TALEN (PubMed=28928128).
CC   Sequence variation: Mutation; HGNC; 7133; KMT2D; Simple; p.Arg1252Ter (c.3754C>T); ClinVar=VCV000167228; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7133; KMT2D; Simple; p.Gln3158Ter (c.9472C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Gln546Arg (c.1637A>G); ClinVar=VCV000045466; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gln331Arg (c.992A>G); ClinVar=VCV000421319; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1045 ! 22Rv1
SX   Male
AG   Adult
CA   Cancer cell line
DT   Created: 02-07-20; Last updated: 05-10-23; Version: 7
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RX   PubMed=28928128; DOI=10.1158/0008-5472.CAN-17-0320;
RA   Van Etten J.L., Nyquist M.D., Li Y.-M., Yang R.-D., Ho Y., Johnson R.,
RA   Ondigi O., Voytas D.F., Henzler C., Dehm S.M.;
RT   "Targeting a single alternative polyadenylation site coordinately
RT   blocks expression of androgen receptor mRNA splice variants in
RT   prostate cancer.";
RL   Cancer Res. 77:5228-5235(2017).
//