Cellosaurus cell line RKO SIRT1 KO (CVCL

Cross-references
Cell line name	RKO SIRT1 KO
Accession	CVCL_ZC46
Resource Identification Initiative	To cite this cell line use: RKO SIRT1 KO (RRID:CVCL_ZC46)
Comments	From: Li, Xiao-Ling; National Institute of Environmental Health Sciences, NIH; Bethesda; USA. Knockout cell: Method=CRISPR/Cas9; HGNC; 14929; SIRT1. Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations	Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
Disease	Colon carcinoma (NCIt: C4910)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0504 (RKO)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Cell line collections (Providers)	Kerafast; ENH132-FP
Cell line databases/resources	cancercelllines; CVCL_ZC46
Encyclopedic resources	Wikidata; Q98128927
Entry history
Entry creation	02-Jul-2020
Last entry update	10-Sep-2024
Version number	7