ID   HT TRAF6 KD
AC   CVCL_ZC30
SY   TRAF6 Knock Down HT
DR   cancercelllines; CVCL_ZC30
DR   Kerafast; EMI026
DR   Wikidata; Q98126737
RX   PubMed=30165192;
CC   Population: Caucasian.
CC   Knockout cell: Method=shRNA knockdown; HGNC; 12036; TRAF6.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val216Met (c.646G>A); ClinVar=VCV000182965; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C36080; Diffuse large B-cell lymphoma germinal center B-cell type
DI   ORDO; Orphanet_544; Diffuse large B-cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1290 ! HT
SX   Male
AG   70Y
CA   Cancer cell line
DT   Created: 02-07-20; Last updated: 05-10-23; Version: 7
//
RX   PubMed=30165192; DOI=10.1016/j.canlet.2018.08.020;
RA   Qu C.-J., Kunkalla K., Vaghefi A., Frederiksen J.K., Liu Y.-D.,
RA   Chapman J.R., Blonska M., Bernal-Mizrachi L., Alderuccio J.P.,
RA   Lossos I.S., Landgraf R., Vega-Vazquez F.;
RT   "Smoothened stabilizes and protects TRAF6 from degradation: a novel
RT   non-canonical role of smoothened with implications in lymphoma
RT   biology.";
RL   Cancer Lett. 436:149-158(2018).
//