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Cellosaurus DLD-1 SIRT1 Het (CVCL_ZC13)

[Text version]
Cell line name DLD-1 SIRT1 Het
Synonyms DLD1 SIRT1 Het; SIRT1 Het DLD1
Accession CVCL_ZC13
Resource Identification Initiative To cite this cell line use: DLD-1 SIRT1 Het (RRID:CVCL_ZC13)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:14929; SIRT1 (Note=1 of 2 alleles).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0248 (DLD-1)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=28162896; DOI=10.1016/j.cub.2016.12.047; PMCID=PMC5319916
Ren N.S.-X., Ji M., Tokar E.J., Busch E.L., Xu X.-J., Lewis D., Li X.-C., Jin A.-W., Zhang Y.-P., Wu W.K.-K., Huang W.-C., Li L.-P., Fargo D.C., Keku T.O., Sandler R.S., Li X.-L.
Haploinsufficiency of SIRT1 enhances glutamine metabolism and promotes cancer development.
Curr. Biol. 27:483-494(2017)

Cross-references
Encyclopedic resources Wikidata; Q98125875
Entry history
Entry creation02-Jul-2020
Last entry update19-Dec-2024
Version number7