ID   SK-astrocyte-IDH1
AC   CVCL_Z595
DR   Wikidata; Q54953609
RX   PubMed=22343889;
CC   From: Memorial Sloan Kettering Cancer Center; New York; USA.
CC   Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK2012-113.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5382; IDH1.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
CC   Cell type: Astrocyte; CL=CL_0000127.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_E3G4 ! NHA E6/E7/hTERT/Ras
SX   Sex unspecified
AG   Age unspecified
CA   Telomerase immortalized cell line
DT   Created: 10-04-15; Last updated: 19-12-24; Version: 10
//
RX   PubMed=22343889; DOI=10.1038/nature10866; PMCID=PMC3351699;
RA   Turcan S., Rohle D., Goenka A., Walsh L.A., Fang F., Yilmaz E.,
RA   Campos C., Fabius A.W.M., Lu C., Ward P.S., Thompson C.B., Kaufman A.,
RA   Guryanova O., Levine R., Heguy A., Viale A.J., Morris L.G.T., Huse J.T.,
RA   Mellinghoff I.K., Chan T.A.;
RT   "IDH1 mutation is sufficient to establish the glioma hypermethylator
RT   phenotype.";
RL   Nature 483:479-483(2012).
//