ID   Caco-2/PD-7
AC   CVCL_Z580
SY   Caco-2/PD7; Caco2/PD7; PD-7; PD7
DR   cancercelllines; CVCL_Z580
DR   Wikidata; Q54808326
RX   DOI=10.1016/0378-5173(94)00280-I;
RX   PubMed=8175910;
RX   PubMed=15868485;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0025 ! Caco-2
SX   Male
AG   72Y
CA   Cancer cell line
DT   Created: 10-04-15; Last updated: 05-10-23; Version: 12
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RX   DOI=10.1016/0378-5173(94)00280-I;
RA   Caro I., Boulenc X., Rousset M., Meunier V., Bourrie M., Julian B.,
RA   Joyeux H., Roques C., Berger Y., Zweibaum A., Fabre G.;
RT   "Characterisation of a newly isolated Caco-2 clone (TC-7), as a model
RT   of transport processes and biotransformation of drugs.";
RL   Int. J. Pharmaceut. 116:147-158(1995).
//
RX   PubMed=8175910; DOI=10.1242/jcs.107.1.213;
RA   Chantret I., Rodolosse A., Barbat A., Dussaulx E., Brot-Laroche E.,
RA   Zweibaum A., Rousset M.;
RT   "Differential expression of sucrase-isomaltase in clones isolated from
RT   early and late passages of the cell line Caco-2: evidence for
RT   glucose-dependent negative regulation.";
RL   J. Cell Sci. 107:213-225(1994).
//
RX   PubMed=15868485; DOI=10.1007/s10565-005-0085-6;
RA   Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A.,
RA   Zucco F.;
RT   "The Caco-2 cell line as a model of the intestinal barrier: influence
RT   of cell and culture-related factors on Caco-2 cell functional
RT   characteristics.";
RL   Cell Biol. Toxicol. 21:1-26(2005).
//