Cellosaurus cell line (CVCL

Cellosaurus (CVCL_Z361)

Comments

Group: Triple negative breast cancer (TNBC) cell line.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: EGFR genetic alteration cell panel (ATCC TCP-1027).
Part of: JWGray breast cancer cell line panel.
Part of: ICBP43 breast cancer cell line panel.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: NCI-60 cancer cell line panel.
Population: African American.
Doubling time: 40.6 hours (PubMed=32576280); ~30-40 hours (DSMZ=ACC-738); 62 hours (NCI-DTP=MDA-MB-468); ~47 hours (PBCF); 79.76 hours (JWGray panel).
Microsatellite instability: Stable (MSS) (PubMed=15677628; Sanger).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Fluorescence phenotype profiling.
Omics: Genome sequenced.
Omics: Glycoproteome analysis by proteomics.
Omics: H2BK120ub ChIP-seq epigenome analysis.
Omics: H3K23ac ChIP-seq epigenome analysis.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: H3K27me3 ChIP-seq epigenome analysis.
Omics: H3K36me3 ChIP-seq epigenome analysis.
Omics: H3K4me1 ChIP-seq epigenome analysis.
Omics: H3K4me3 ChIP-seq epigenome analysis.
Omics: H3K79me2 ChIP-seq epigenome analysis.
Omics: H3K9ac ChIP-seq epigenome analysis.
Omics: H3K9me3 ChIP-seq epigenome analysis.
Omics: H4K8ac ChIP-seq epigenome analysis.
Omics: lncRNA expression profiling.
Omics: Metabolome analysis.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.

Sequence variations

Mutation; HGNC; HGNC:9588; PTEN; Simple; c.253+1G>T; ClinVar=VCV000189475; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=19593635).
Mutation; HGNC; HGNC:9884; RB1; Simple; c.265_2787del2523; Zygosity=Homozygous (PubMed=19593635).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (PubMed=1961733; PubMed=16541312; PubMed=28889351; ATCC=HTB-132).

HLA typing

Source: PubMed=25960936

Class I
HLA-A	A*23:01,30:02
HLA-B	B*27:03,53:01
HLA-C	C*02:02,04:01

Source: PubMed=26589293

Class I
HLA-A	A*23:01,30:02
HLA-B	B*27:03,53:01
HLA-C	C*02:02,04:01
Class II
HLA-DQ	DQA1*02:01,05:02
	DQB1*03:04,06:13
HLA-DR	DRB1*04:03,13:100

Genome ancestry

Source: PubMed=30894373

Origin	% genome
African	80.3
Native American	0
East Asian, North	6.19
East Asian, South	0
South Asian	0
European, North	0
European, South	13.51

Disease

Breast adenocarcinoma (NCIt: C5214)

Species of origin

Aedes malayensis (Mosquito) (Stegomyia malayensis) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

51Y

Category

Cancer cell line

STR profile

Source(s): AddexBio=C0006003/4673; ATCC=HTB-132; CCRID; Cosmic-CLP=908123; DSMZ=ACC-738; PubMed=25877200; PubMed=28889351; Technion Genomics Center

Markers:

Amelogenin	X
CSF1PO	12
D10S1248	13
D12S391	18
D13S317	12
D16S539	9
D18S51	17
D19S433	12,13
D1S1656	11,14
D21S11	27 (CCRID) 27,28 (ATCC=HTB-132; DSMZ=ACC-738; PubMed=25877200; PubMed=28889351; Technion Genomics Center)
D22S1045	10
D2S1338	17,25
D2S441	12,14
D3S1358	15
D5S818	12
D7S820	8
D8S1179	13
FGA	23
Penta D	8,10
Penta E	5
TH01	7
TPOX	8,9
vWA	18

Web pages

https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-53.html
https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
https://tcpaportal.org/mclp/

Entry history

Entry creation

04-Apr-2012

Last entry update

19-Dec-2024

Version number