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Cellosaurus (CVCL_Z360)

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Comments Group: Triple negative breast cancer (TNBC) cell line.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: EGFR genetic alteration cell panel (ATCC TCP-1027).
Part of: JWGray breast cancer cell line panel.
Part of: ICBP43 breast cancer cell line panel.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: NCI-60 cancer cell line panel.
Population: African American.
Doubling time: 40.6 hours (PubMed=32576280); ~30-40 hours (DSMZ=ACC-738); 62 hours (NCI-DTP=MDA-MB-468); ~47 hours (PBCF); 79.76 hours (JWGray panel).
Microsatellite instability: Stable (MSS) (PubMed=15677628; Sanger).
Omics: Array-based CGH.
Omics: CNV analysis.
Omics: CRISPR phenotypic screen.
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Fluorescence phenotype profiling.
Omics: Genome sequenced.
Omics: Glycoproteome analysis by proteomics.
Omics: H2BK120ub ChIP-seq epigenome analysis.
Omics: H3K23ac ChIP-seq epigenome analysis.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: H3K27me3 ChIP-seq epigenome analysis.
Omics: H3K36me3 ChIP-seq epigenome analysis.
Omics: H3K4me1 ChIP-seq epigenome analysis.
Omics: H3K4me3 ChIP-seq epigenome analysis.
Omics: H3K79me2 ChIP-seq epigenome analysis.
Omics: H3K9ac ChIP-seq epigenome analysis.
Omics: H3K9me3 ChIP-seq epigenome analysis.
Omics: H4K8ac ChIP-seq epigenome analysis.
Omics: lncRNA expression profiling.
Omics: Metabolome analysis.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
HLA typing Source: PubMed=25960936
Class I
HLA-AA*23:01,30:02
HLA-BB*27:03,53:01
HLA-CC*02:02,04:01

Source: PubMed=26589293
Class I
HLA-AA*23:01,30:02
HLA-BB*27:03,53:01
HLA-CC*02:02,04:01
Class II
HLA-DQDQA1*02:01,05:02
DQB1*03:04,06:13
HLA-DRDRB1*04:03,13:100
Genome ancestry Source: PubMed=30894373

Origin% genome
African80.3
Native American0
East Asian, North6.19
East Asian, South0
South Asian0
European, North0
European, South13.51
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Anopheles gambiae (African malaria mosquito) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0006003/4673; ATCC=HTB-132; CCRID; Cosmic-CLP=908123; DSMZ=ACC-738; PubMed=25877200; PubMed=28889351; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO12
D10S124813
D12S39118
D13S31712
D16S5399
D18S5117
D19S43312,13
D1S165611,14
D21S1127 (CCRID)
27,28 (ATCC=HTB-132; DSMZ=ACC-738; PubMed=25877200; PubMed=28889351; Technion Genomics Center)
D22S104510
D2S133817,25
D2S44112,14
D3S135815
D5S81812
D7S8208
D8S117913
FGA23
Penta D8,10
Penta E5
TH017
TPOX8,9
vWA18

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/MDA-MB-468
https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
https://www.atcc.org/en/support/technical-support/faqs/htb-132-normal-growth-and-morphology
https://www.synapse.org/#!Synapse:syn31544498
https://www.cellosaurus.org/pawefish/BreastCellLineDescriptions/mda-mb-468.html
http://dpsc.ccbr.utoronto.ca/cancer/get_cellline.pl?cellline=MDA-MB-468
https://lincs.hms.harvard.edu/resources/reagents/icbp43/
https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-53.html
https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
https://tcpaportal.org/mclp/
Publications

















Moore G.E., Ito E., Ulrich K., Sandberg A.A.
Culture of human leukemia cells.
Cancer 19:713-723(1966)



Arylsulfatase B deficiency in Maroteaux-Lamy syndrome: cellular studies and carrier identification.
Pediatr. Res. 9:475-480(1975)




Cancer Res. 37:2918-2929(1977)


Rae P.A., Yip C.C., Schimmer B.P.
Isolation of cloned Syrian hamster insulinoma cell lines with limited capacity for insulin production.
Can. J. Physiol. Pharmacol. 57:819-824(1979)



Respiration-deficient Chinese hamster cell mutants: genetic characterization.
Somatic Cell Genet. 5:225-240(1979)




Can. J. Fish. Aquat. Sci. 37:1070-1075(1980)




Proc. Natl. Acad. Sci. U.S.A. 77:4113-4117(1980)



ovary cell.
Somatic Cell Genet. 9:165-173(1983)


Hill S.M., Rodgers C.S., Hulten M.A., Wilson A.P.
Cytogenetics of a cell line derived from an ovarian papillary serous cystadenocarcinoma.
Cancer Genet. Cytogenet. 12:321-327(1984)



Characterization of three human malignant mesothelioma cell lines.
Cancer Genet. Cytogenet. 42:115-128(1989)




Oncogene 6:2033-2040(1991)



Epstein-Barr virus DNA recombines via latent origin of replication with the human genome in the lymphoblastoid cell line RGN1.
J. Virol. 66:5677-5681(1992)


Gazdar A.F., Minna J.D.
High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors.
Oncogene 7:339-346(1992)



sarco/endoplasmic reticulum Ca2+ transport ATPase in thapsigargin-resistant hamster smooth muscle cells.
Nucleic Acids Res. 26:4529-4537(1998)


Zheng J.L., Lewis A.K., Gao W.-Q.
Establishment of conditionally immortalized rat utricular epithelial cell lines using a retrovirus-mediated gene transfer technique.
Hear. Res. 117:13-23(1998)


Osborne B.
Characterization of a mutant T-cell hybridoma line with defects in the TCR-mediated apoptotic pathway.
Cell Death Differ. 6:36-47(1999)



Coexistence of two distinct cell populations (CD56(+)TcRgammadelta(+) and CD56(+)TcRgammadelta(-)) in a case of aggressive CD56(+) lymphoma/leukemia.
Haematologica 85:496-501(2000)




Mol. Cell. Biol. 24:2842-2852(2004)


Stojkoski A., Glorion C., Jaubert F.
DOR-1, A novel CD10+ stromal cell line derived from progressive Langerhans cell histiocytosis of bone.
Pediatr. Blood Cancer 44:128-137(2005)



squamous cell carcinoma.
Cancer Sci. 97:1351-1358(2006)


Redon R., Ishikawa S., Fitch K.R., Feuk L., Perry G.H., Andrews T.D., Fiegler H., Shapero M.H., Carson A.R., Chen W.-W., Cho E.K., Dallaire S., Freeman J.L., Gonzalez J.R., Gratacos M., Huang J., Kalaitzopoulos D., Komura D., MacDonald J.R., Marshall C.R., Mei R., Montgomery L., Nishimura K., Okamura K., Shen F., Somerville M.J., Tchinda J., Valsesia A., Woodwark C., Yang F.-T., Zhang J.-J., Zerjal T., Zhang J., Armengol L., Conrad D.F., Estivill X., Tyler-Smith C., Carter N.P., Aburatani H., Lee C., Jones K.W., Scherer S.W., Hurles M.E.
Global variation in copy number in the human genome.
Nature 444:444-454(2006)


Taylor D.D., Gercel-Taylor C.
MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
Gynecol. Oncol. 110:13-21(2008)


Chen W.-B., Xie M., Wang W.-L., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W., Fan H.C., Wang J.-B., Gui Y.-T., Lee K.H., Betenbaugh M.J., Quake S.R., Famili I., Palsson B.O., Wang J.
The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.
Nat. Biotechnol. 29:735-741(2011)


Elia G., Marincola F.M., McCubrey J.A., Libra M., Travali S., Kane M.
Characterization of human melanoma cell lines and melanocytes by proteome analysis.
Cell Cycle 10:2924-2936(2011)



Immunopurification of adenomatous polyposis coli (APC) proteins.
BMC Res. Notes 6:429.1-429.8(2013)


Maruyama K., Hori O., Hibino S., Choshi T., Nakahata T., Hioki H., Kaneko T., Naitoh M., Yoshikawa K., Yamawaki S., Suzuki S., Hata R., Ueno S.-i., Seki T., Kobayashi K., Toda T., Murakami K., Irie K., Klein W.L., Mori H., Asada T., Takahashi R., Iwata N., Yamanaka S., Inoue H.
Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Abeta and differential drug responsiveness.
Cell Stem Cell 12:487-496(2013)


Kosaka A., Ohkuri T., Okada H.
Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells.
Cancer Immunol. Immunother. 63:847-857(2014)



juveniles.
Bull. Eur. Assoc. Fish Pathol. 36:155-163(2016)



Tumour resistance in induced pluripotent stem cells derived from naked mole-rats.
Nat. Commun. 7:11471.1-11471.9(2016)



modeling.
Stem Cell Res. 23:73-76(2017)


Robison R.A., O'Neill K.L.
Non-small-cell lung cancer cell lines A549 and NCI-H460 express hypoxanthine guanine phosphoribosyltransferase on the plasma membrane.
Onco Targets Ther. 10:1921-1932(2017)


Baryshnikova M.A.
Characteristics of Mel Ibr melanoma line subclone after treatment with chicken embryo extract.
Bull. Exp. Biol. Med. 163:255-259(2017)




Cancer Sci. 109:3171-3182(2018)



evaluating anti-cancer drug resistant cell lines.
BMC Cancer 21:1049.1-1049.13(2021)



Correction to: Aurora B kinase as a therapeutic target in acute lymphoblastic leukemia.
Cancer Chemother. Pharmacol. 88:1055-1056(2021)

Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number50