ID   BTI-Tnao38
AC   CVCL_Z252
SY   Tnao38; Ao38
DR   BioSample; SAMN06481107
DR   ICLDB; bti-tnao38
DR   Wikidata; Q54798603
RX   PubMed=20602790;
RX   PubMed=22531032;
RX   PubMed=24375231;
RX   PubMed=29133148;
CC   Group: Insect cell line.
CC   Group: Recombinant protein production insect cell line.
CC   Problematic cell line: Contaminated. Originally thought to be from Ascalapha odorata. Shown to be a BTI-Tn-5B1-4 derivative (PubMed=22531032).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00510.
CC   Doubling time: 20.2 hours (PubMed=20602790).
OX   NCBI_TaxID=7111; ! Trichoplusia ni (Cabbage looper)
HI   CVCL_C190 ! BTI-Tn-5B1-4
SX   Sex unspecified
AG   Embryonic stage
CA   Spontaneously immortalized cell line
DT   Created: 10-04-15; Last updated: 21-03-23; Version: 13
RX   PubMed=20602790; DOI=10.1186/1472-6750-10-50;
RA   Hashimoto Y., Zhang S., Blissard G.W.;
RT   "Ao38, a new cell line from eggs of the black witch moth, Ascalapha
RT   odorata (Lepidoptera: Noctuidae), is permissive for AcMNPV infection
RT   and produces high levels of recombinant proteins.";
RL   BMC Biotechnol. 10:50.1-50.16(2010).
RX   PubMed=22531032; DOI=10.1186/1472-6750-12-12;
RA   Hashimoto Y., Zhang S., Zhang S., Chen Y.-R., Blissard G.W.;
RT   "Correction: BTI-Tnao38, a new cell line derived from Trichoplusia ni,
RT   is permissive for AcMNPV infection and produces high levels of
RT   recombinant proteins.";
RL   BMC Biotechnol. 12:12.1-12.4(2012).
RX   PubMed=24375231; DOI=10.1007/s10529-013-1429-6;
RA   Wilde M., Klausberger M., Palmberger D., Ernst W., Grabherr R.;
RT   "Tnao38, high five and Sf9 -- evaluation of host-virus interactions in
RT   three different insect cell lines: baculovirus production and
RT   recombinant protein expression.";
RL   Biotechnol. Lett. 36:743-749(2014).
RX   PubMed=29133148; DOI=10.1016/j.pep.2017.11.002;
RA   Geisler C., Jarvis D.L.;
RT   "Adventitious viruses in insect cell lines used for recombinant
RT   protein expression.";
RL   Protein Expr. Purif. 144:25-32(2017).