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Cellosaurus A549 DHODH-/- (CVCL_YZ46)

[Text version]
Cell line name A549 DHODH-/-
Synonyms DHODH-/- A549
Accession CVCL_YZ46
Resource Identification Initiative To cite this cell line use: A549 DHODH-/- (RRID:CVCL_YZ46)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; 2867; DHODH.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=32754890; DOI=10.1007/s13238-020-00768-w
Xiong R., Zhang L.-K., Li S.-L., Sun Y., Ding M.-Y., Wang Y., Zhao Y.-L., Wu Y., Shang W.-J., Jiang X.-M., Shan J.-W., Shen Z.-H., Tong Y., Xu L.-X., Chen Y., Liu Y.-L., Zou G., Lavillete D., Zhao Z.-J., Wang R., Zhu L.-L., Xiao G.-F., Lan K., Li H.-L., Xu K.
Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
Protein Cell 11:723-739(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YZ46
Encyclopedic resources Wikidata; Q98125454
Entry history
Entry creation02-Jul-2020
Last entry update05-Oct-2023
Version number6