ID   MCF7-LTED
AC   CVCL_YX84
SY   MCF7 LTED; LTED-I; MCF7-Long Term Estrogen-Deprived
DR   cancercelllines; CVCL_YX84
DR   Wikidata; Q95986792
RX   PubMed=12775708;
RX   PubMed=26116361;
CC   Population: Caucasian.
CC   Characteristics: Derived from parent cell line by long-term culture in the presence of RPMI-1640 medium containing 10% dextran charcoal stripped serum (DCC) (PubMed=26116361).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 12-03-20; Last updated: 05-10-23; Version: 9
//
RX   PubMed=12775708; DOI=10.1074/jbc.M305226200;
RA   Martin L.-A., Farmer I., Johnston S.R.D., Ali S., Marshall C.J.,
RA   Dowsett M.;
RT   "Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal
RT   transduction pathways operate during the adaptation of MCF-7 cells to
RT   long term estrogen deprivation.";
RL   J. Biol. Chem. 278:30458-30468(2003).
//
RX   PubMed=26116361; DOI=10.1158/1535-7163.MCT-15-0143;
RA   Ribas R., Pancholi S., Guest S.K., Marangoni E., Gao Q., Thuleau A.,
RA   Simigdala N., Polanska U.M., Campbell H., Rani A., Liccardi G.,
RA   Johnston S.R.D., Davies B.R., Dowsett M., Martin L.-A.;
RT   "AKT antagonist AZD5363 influences estrogen receptor function in
RT   endocrine-resistant breast cancer and synergizes with fulvestrant
RT   (ICI182780) in vivo.";
RL   Mol. Cancer Ther. 14:2035-2048(2015).
//