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Cellosaurus NCC-MPNST1-C1 (CVCL_YU12)

[Text version]
Cell line name NCC-MPNST1-C1
Synonyms NCCMPNST1C1
Accession CVCL_YU12
Resource Identification Initiative To cite this cell line use: NCC-MPNST1-C1 (RRID:CVCL_YU12)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: NCC sarcoma cell line panel.
Population: Japanese.
Senescence: It is possible that this cell line is not immortal and has a finite life span (personal communication of Kondo T.).
Doubling time: 28 hours (PubMed=32099531).
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=32099531).
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (PubMed=32099531).
  • Gene deletion; HGNC; 12362; TSC1; Zygosity=Homozygous (PubMed=32099531).
  • Mutation; HGNC; 1101; BRCA2; Simple; p.Lys1872Ter (c.5614A>T); ClinVar=VCV000037979; Zygosity=Heterozygous (PubMed=32099531).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 37Y
Category Cancer cell line
STR profile Source(s): PubMed=32099531

Markers:
AmelogeninX
CSF1PO12
D5S8187,13
D7S82010.3,11
D13S31711,12
D16S53910,11
D21S1130,31
TH016
TPOX11
vWA17,18

Run an STR similarity search on this cell line
Web pages https://en.cellline.jp/product/ncc-mpnst1-c1/
Publications

PubMed=32099531; DOI=10.1186/s12935-020-1128-z
Oyama R., Kito F., Takahashi M., Hattori E., Noguchi R., Takai Y., Sakumoto M., Qiao Z.-W., Toki S., Sugawara M., Tanzawa Y., Kobayashi E., Nakatani F., Iwata S., Yoshida A., Kawai A., Kondo T.
Establishment and characterization of patient-derived cancer models of malignant peripheral nerve sheath tumors.
Cancer Cell Int. 20:58.1-58.15(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YU12
DepMap; ACH-002799
Encyclopedic resources Wikidata; Q95992534
Entry history
Entry creation12-Mar-2020
Last entry update30-Jan-2024
Version number9