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Cellosaurus HL-60/5FU (CVCL_YP33)

[Text version]
Cell line name HL-60/5FU
Accession CVCL_YP33
Resource Identification Initiative To cite this cell line use: HL-60/5FU (RRID:CVCL_YP33)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:46345; 5-fluorouracil (5-FU).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=31741260; DOI=10.1007/s11033-019-05017-w
Dlugosz-Pokorska A., Pieta M., Janecki T., Janecka A.
New uracil analogs as downregulators of ABC transporters in 5-fluorouracil-resistant human leukemia HL-60 cell line.
Mol. Biol. Rep. 46:5831-5839(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YP33
Encyclopedic resources Wikidata; Q94211538
Entry history
Entry creation12-Mar-2020
Last entry update05-Oct-2023
Version number9